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Zoldix (5mg/100ml) IV Infusion | [For osteoporosis]
Zoledronic Acid is a potent bisphosphonate that inhibits osteoclast-mediated bone resorption. Its action is due to a strong affinity for mineralized bone, particularly at sites of high turnover. The primary molecular target is farnesyl pyrophosphate synthase in osteoclasts, leading to reduced bone breakdown. Its long duration of effect is attributed to strong binding with bone mineral.
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ফ্রি ডেলিভারিঃ - ৯৯৯ টাকা+ অর্ডারে, ঢাকা
শহরে- ফ্রি ডেলিভারিঃ - ২৯৯৯ টাকা+ অর্ডারে, ঢাকার
বাহিরে
✅ Description:
Zoldix is prescribed for:
- Treatment and prevention of postmenopausal osteoporosis
- Increasing bone mass in men with osteoporosis
- Management and prevention of glucocorticoid-induced osteoporosis
- Treatment of Paget’s disease of bone in both men and women
Limitations of use: The optimal duration of therapy is not clearly established. For patients at low fracture risk, discontinuation should be considered after 3–5 years of use.
- Pediatric: Not indicated.
- Geriatric: Monitor renal function closely.
- Renal impairment: Contraindicated if CrCl <35 mL/min.
- Hepatic impairment: No adjustment needed (not metabolized hepatically).
- Pregnancy & Lactation: Contraindicated – may cause fetal harm and not recommended during breastfeeding.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Dosage & Administration | Zoldix
Postmenopausal Osteoporosis (treatment): 5 mg IV infusion once yearly (≥15 minutes).
Postmenopausal Osteoporosis (prevention): 5 mg IV infusion every 2 years.
Osteoporosis in Men: 5 mg IV infusion once yearly.
Glucocorticoid-Induced Osteoporosis: 5 mg IV infusion once yearly.
Paget’s Disease: A single 5 mg IV infusion (≥15 minutes).
Re-treatment may be required if symptoms return or serum alkaline phosphatase fails to normalize.
Supplementation:
Patients should receive Calcium (≥1200–1500 mg/day) and Vitamin D (800–1000 IU/day), particularly during the first 2 weeks after infusion.
Administration guidelines:
- Infusion time must be ≥15 minutes.
- Ensure patients are well-hydrated.
- Flush IV line with 10 mL normal saline post-infusion.
- Avoid mixing with calcium-containing solutions.
- If refrigerated, bring to room temperature before use.
✔️ Side Effects | Zoldix
Common (>10%): Pyrexia, myalgia, headache, arthralgia, extremity pain
Others: Flu-like illness, nausea, vomiting, diarrhea, eye inflammation
Serious: Osteonecrosis of the jaw (ONJ), atypical femur fractures, renal impairment
✔️ Drug Interactions
- Aminoglycosides: Prolonged hypocalcemia risk.
- Loop diuretics: Increased risk of hypocalcemia.
- Nephrotoxic drugs: Enhanced renal toxicity.
- Renally cleared drugs: Increased exposure in renal impairment.
✔️ Overdose Management
Overdosage may result in renal failure, hypocalcemia, hypophosphatemia, and hypomagnesemia. Treat with IV supplementation (calcium gluconate, phosphate, magnesium sulfate). Maximum single dose: 5 mg IV over ≥15 minutes.
✔️ Storage
- Store below 30°C, protected from light and moisture.
- Keep out of reach of children.
- Once opened, the solution is stable for 24 hours at 2–8°C.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
