Perinase 50µg Nasal Spray Price in Bangladesh

✔️ Uses of Perinase 50µg Nasal Spray

Sneezing and runny nose due to allergies

✔️ How does Perinase 50µg Nasal Spray work?

Perinase is a steroid which works by blocking the production of certain chemical messengers in the body that cause inflammation (redness and swelling) and allergies.

✔️ Side Effects of Perinase 50µg Nasal Spray

• Nasal irritation
• Nosebleed
• Headache

✔️ Quick Suggestions:

• Avoid deep breathing as it will cause medication to go back to the throat.
• Do not share the bottle to prevent spreading germs.
• Avoid using Perinase if you have recent nasal ulcers, nasal surgery, or nasal trauma.

✔️ Indication of Perinase 50µg Nasal Spray

Perinase is a synthetic trifluorinated corticosteroid with anti-inflammatory activity. It is an aqueous suspension of microfine fluticasone propionate for topical administration to the nasal mucosa through a metering, atomizing spray pump. Each bottle of Perinase Nasal Spray provides 120 metered sprays.

✔️ Pharmacology

Following topical administration into the nasal mucosa, fluticasone propionate produces anti-inflammatory and vasoconstrictor effects. The exact mechanism of these actions remains unknown but may involve:

• Reduction in the number of mediator cells (basophils, leukocytes, and mast cells) at the epithelial level
• Reduction in the number of eosinophils
• Decreased sensitivity of sensory nerves to mechanical stimuli
• Decreased secretory response to cholinergic receptor stimulation
• Inhibition of fibroblast activity
• Inhibition of capillary dilation and permeability
• Stabilization of lysosomal membranes and prevention of proteolytic enzyme release

✔️ Dosage of Perinase 50µg Nasal Spray

Adults & children over 12 years:

• 2 sprays in each nostril once a day, preferably in the morning.
• In some cases, 2 sprays into each nostril twice daily, not exceeding 4 sprays.

Children under 12 years (4-11 years):

• 1 spray in each nostril once a day.
• The maximum total daily dosage should not exceed 4 sprays.
• For perennial rhinitis in children, there is insufficient clinical data to recommend its use.

Children below 4 years:

• The safety and effectiveness of fluticasone propionate nasal spray in children below 4 years of age have not been established.

Patients should use fluticasone propionate nasal spray at regular intervals as directed since its effectiveness depends on its regular use. Or as directed by the physician.

✔️ How to use the Nasal Spray:

1. Shake the bottle gently and remove the dust cover.
2. Hold the spray with your forefinger and middle finger on either side of the nozzle and your thumb underneath the bottle. Press down until a fine spray appears. If using it for the first time or if you have not used it for a week or more, press the nasal applicator several times until a fine mist comes out from the container.
3. Gently blow the nose to clear the nostrils.
4. Close one nostril and carefully insert the nasal applicator into the open nostril. Tilt your head forward slightly and keep the spray upright. Breathe in through your nose and while breathing in, press the white collar of the nasal applicator firmly down once to release a spray.
5. Breathe out through your mouth.
6. Repeat the above steps in the same/other nostril for consecutive doses.

✔️ Cleaning of Perinase Nasal Spray

1. Remove the dust cover.
2. Gently pull off the nasal applicator.
3. Wash the applicator and dust cover in warm water.
4. Shake off the excess water and leave to dry in a normal place. Avoid applying additional heat.
5. Gently push the applicator back on the top of the bottle and re-fix the dust cover.

✔️ Interaction

This may lead to increased plasma concentrations of fluticasone when used with CYP4503A4 inhibitors such as ritonavir.

✔️ Contraindications

Fluticasone propionate nasal spray is contraindicated in patients with hypersensitivity to any of its ingredients.

✔️ Pregnancy & Lactation

Pregnancy:

• Available data on inhaled or intranasal fluticasone propionate use in pregnant women have not reported a clear association with adverse developmental outcomes.
• Fluticasone propionate crossed the placenta following subcutaneous administration to mice and rats and oral administration to rabbits.
• Use during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Lactation:

• There are no available data on fluticasone propionate in human milk, its effects on breastfed children, or its effects on milk production.
• Consider the benefits of breastfeeding along with any potential adverse effects from treatment.

✔️ Precautions & Warnings

• Rare instances of wheezing, nasal septum perforation, cataracts, glaucoma, and increased intraocular pressure have been reported following the intranasal application of corticosteroids, including Perinase.
• Although systemic effects have been minimal with recommended doses of Perinase nasal spray, the potential risk increases with larger doses. Therefore, larger than recommended doses of Perinase nasal spray should be avoided.

✔️ Storage Conditions:

Keep all medicines out of reach of children. Store in a cool and dry place protected from light.