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Tevirax is prescribed for the treatment of chronic hepatitis B virus (HBV) infection in adults with compensated liver disease.
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বাহিরে
✅ Description:
Tevirax is a nucleoside analog reverse transcriptase inhibitor. It works as follows:
- Tevirax enters liver cells (hepatocytes) via passive diffusion and specific transporters (OATP1B1, OATP1B3).
- Inside the cells, it is converted into tenofovir, which is then phosphorylated to its active form, tenofovir diphosphate.
- Tenofovir diphosphate blocks HBV replication by terminating viral DNA chains, preventing the virus from multiplying.
It has minimal effect on human DNA polymerases, including mitochondrial DNA polymerase γ, so mitochondrial toxicity is unlikely.
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✔️ Side Effects
Headache, stomach pain, fatigue, cough, nausea, back pain
Serious (requires medical attention):
- Lactic acidosis or severe liver enlargement with fat buildup
- Severe flare-ups of hepatitis B after stopping treatment
- New or worsening kidney problems, including Fanconi syndrome
✔️ Dosage & Administration
Adult Dose:
Standard dose: 25 mg (1 tablet) orally once daily with food.
Renal Impairment:
No adjustment needed if creatinine clearance (CrCl) ≥15 mL/min or in patients on chronic hemodialysis.
Administer after hemodialysis on dialysis days.
Not recommended for ESRD patients not on hemodialysis.
Hepatic Impairment:
No adjustment for mild hepatic impairment (Child-Pugh A).
Not recommended for decompensated liver disease (Child-Pugh B or C).
Pediatric Use: Safety and effectiveness in patients under 18 years is not established.
Geriatric Use: No significant safety or efficacy differences observed in patients aged ≥65 years.
Important:
Test for HIV before starting Tevirax; do not use alone in patients with HIV.
✔️ Drug Interactions
Tevirax is affected by P-gp and BCRP inhibitors or inducers, which can increase or decrease drug absorption.
Drugs that affect renal function or compete for active tubular secretion may raise tenofovir levels and increase side effects. Examples include acyclovir, ganciclovir, aminoglycosides, high-dose NSAIDs, and others.
✔️ Pregnancy & Lactation
Pregnancy: Limited data show a small risk of birth defects; weigh benefits vs. risks.
Breastfeeding: Unknown if excreted in human milk. Consider breastfeeding benefits versus potential drug risks.
✔️ Precautions & Warnings
Hepatitis B exacerbation: Monitor closely after stopping treatment; therapy may need to resume.
HIV resistance risk: Do not use alone in patients with HBV/HIV co-infection. HIV testing is required before treatment.
Kidney monitoring: Regularly check serum creatinine, urine protein/glucose, and phosphorus (if chronic kidney disease).
Lactic acidosis/hepatotoxicity: Stop Tevirax immediately if severe symptoms develop.
✔️ Storage:
Store below 30°C in the original container.
Protect from light and moisture.
Keep out of reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
