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Teviral 0.5 (Entecavir 0.5 mg)
Therapeutic Class: Antiviral agent (Nucleoside analogue)
- Chronic Hepatitis B Virus (HBV) infection in adults and children ≥2 years with evidence of active viral replication and either:
- Persistent elevation in serum aminotransferases (ALT/AST), or
- Histologically active disease
- HIV infection (as part of combination therapy, but not recommended as monotherapy for HIV).
Pregnancy: Limited human data; insufficient to assess teratogenic risk. Animal studies showed entecavir in breast milk. Use only if benefit outweighs risk.
Lactation: Unknown if excreted in human milk; not recommended while breastfeeding.
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শহরে- ফ্রি ডেলিভারিঃ - ২৯৯৯ টাকা+ অর্ডারে, ঢাকার
বাহিরে
✅ Description:
- Entecavir selectively inhibits HBV DNA polymerase, blocking reverse transcriptase activity.
- This suppresses viral DNA synthesis, thereby reducing HBV replication.
- It is not a cure for HBV or HIV, but helps to lower viral load and improve liver health/lifespan.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Patient Counseling Tips
- Take exactly as prescribed, on an empty stomach.
- Do not miss doses; skipping doses can lead to resistance.
- Continue therapy even if symptoms improve, unless advised by doctor.
- Do not share needles, razors, or toothbrushes; practice safe sex.
- Regular follow-up and blood tests are essential.
✔️ Dosage & Administration
Adult Dose:
Treatment-naïve, compensated liver disease: 0.5 mg once daily
Lamivudine-refractory or lamivudine/telbivudine resistance: 1 mg once daily
Decompensated liver disease: 1 mg once daily
Pediatric Dose:
≥2 years & ≥10 kg: dose adjusted by weight
<2 years: safety/efficacy not established
16 years: same as adult dosing
Renal Impairment (dose adjustment):
- CrCl ≥50 mL/min: No adjustment
- CrCl 30–49 mL/min: 0.25 mg/day or 0.5 mg every 48 hr
- CrCl 10–29 mL/min: 0.15 mg/day or 0.5 mg every 72 hr
- CrCl <10 mL/min, hemodialysis, CAPD: 0.05 mg/day or 0.5 mg every 7 days
Oral use, on an empty stomach (≥2 hours before or after a meal).
Swallow the tablet whole with water.
✔️ Side Effects
- Headache (2–4%)
- Fatigue (1–3%)
- Dizziness
- Nausea
- Diarrhea
- Vomiting
- Dyspepsia
- Insomnia
- Rash
- Lactic acidosis
- Severe hepatotoxicity
- Acute flare of hepatitis after withdrawal
✔️ Interaction
- Drugs reducing renal function or competing for active tubular secretion may increase entecavir levels (or vice versa).
- Use cautiously with nephrotoxic agents.
- Limited clinically significant drug interactions otherwise.
✔️ Contraindications:
Hypersensitivity to entecavir or any component of the formulation.
✔️ Precautions & Warnings
- Lactic acidosis and hepatomegaly with steatosis: rare but potentially fatal; monitor closely.
- Severe acute exacerbations of hepatitis may occur after discontinuation – do not stop abruptly without medical supervision.
- Renal impairment: dose adjustment required.
- HIV co-infection: should not be used alone as it may cause HIV resistance.
- Liver monitoring: regular ALT, AST, HBV DNA levels required during and after therapy.
- Alcohol: avoid due to increased risk of liver damage.
✔️ Storage:
Store in cool & dry place below 30°C, protect from light & moisture. Keep out of reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
