Olmenor Plus 5/40mg 10Pcs

Olmenor Plus 5/40mg — Amlodipine Besilate 5mg + Olmesartan Medoxomil 40mg

Olmenor Plus 5/40mg is a fixed-dose combination antihypertensive tablet containing Amlodipine Besilate 5mg (a dihydropyridine calcium channel blocker) and Olmesartan Medoxomil 40mg (an angiotensin II receptor blocker — ARB), manufactured by Drug International Ltd. — a leading pharmaceutical company in Bangladesh.

The two complementary mechanisms of action make Olmenor Plus significantly more effective than either drug alone at equivalent doses, with better tolerability (Amlodipine-associated oedema is reduced when combined with an ARB).

Indications (Uses)

• Hypertension (high blood pressure) in adults whose blood pressure is not adequately controlled on monotherapy
• Hypertension with concurrent type 2 diabetes (renal-protective benefits of ARB)
• Hypertension in patients at high cardiovascular risk (post-MI, chronic kidney disease)
• Reduction of risk of fatal and non-fatal cardiovascular events in hypertensive patients

Mechanism of Action (Pharmacology)

Amlodipine (CCB): Blocks L-type voltage-gated calcium channels in vascular smooth muscle and cardiac cells, causing arterial vasodilation and reducing peripheral vascular resistance — lowering systolic and diastolic blood pressure.

Olmesartan Medoxomil (ARB): Selectively blocks the AT1 angiotensin II receptor, preventing angiotensin II-mediated vasoconstriction, aldosterone secretion, and sodium retention. This independently lowers blood pressure and provides organ-protective effects.

Dosage & Administration

• Adults: 1 tablet (5/40mg) once daily, with or without food
• Standard starting dose: Amlodipine 5mg + Olmesartan 20mg once daily; titrate to 5/40mg after 1–2 weeks if needed
• Maximum dose: Amlodipine 10mg + Olmesartan 40mg once daily
• Take at the same time each day for consistent blood pressure control

Contraindications

• Pregnancy (2nd and 3rd trimesters) — Olmesartan can cause fetal renal dysfunction and death
• Concomitant use with aliskiren in patients with diabetes
• Severe hepatic impairment
• Known hypersensitivity to Amlodipine, Olmesartan, or dihydropyridines

Side Effects

Common: Peripheral oedema (ankle/foot swelling), dizziness, headache, flushing, fatigue.

Uncommon: Hypotension (especially on first dose or if dehydrated), palpitations.

Rare but serious: Sprue-like enteropathy (severe chronic diarrhoea with weight loss — discontinue and seek medical attention), angioedema.

Drug Interactions

• Potassium-sparing diuretics / potassium supplements: Risk of hyperkalaemia with ARBs
• NSAIDs (e.g., ibuprofen): May reduce antihypertensive effect and increase renal impairment risk
• Lithium: ARBs may increase serum lithium levels — monitor closely
• Dual RAAS blockade (ACE inhibitors + ARB): Not recommended — increased risk of hypotension, hyperkalaemia, and renal impairment

Storage

Store below 30°C in a cool, dry place. Protect from light and moisture. Keep out of reach of children.

Substitute Brands in Bangladesh

Other Amlodipine+Olmesartan brands in Bangladesh: Olmezest AM (Sun Pharma), Olmedip (Ibn Sina), Orbapin (Popular Pharma), Olmetor AM (Euro Pharma). Consult your doctor before switching brands.

Consult your doctor or pharmacist before starting or changing your blood pressure medication. Never stop antihypertensive therapy without medical advice.