Propranolol Hydrochloride is a non-selective β-adrenergic blocker that reduces heart rate, myocardial contractility, and oxygen demand by antagonizing catecholamines at β-receptors. It is well absorbed from the GI tract but undergoes first-pass hepatic metabolism. Peak plasma levels occur within 1–1.5 hours. Elimination half-life: 3–6 hours. Metabolites are excreted via urine.
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Adults:
Children (Hypertension):
Cold extremities, nausea, dizziness, fatigue, insomnia, paresthesia.
Caution with verapamil, salbutamol, levosalbutamol, ergot alkaloids, lidocaine, and phenobarbital.
Bronchospasm, cardiogenic shock, AV block (2nd/3rd degree), uncontrolled diabetes mellitus.
Category C: avoid in pregnancy unless necessary.
Excreted in breast milk; use with caution during lactation.
Caution in hepatic/renal impairment, pregnancy, and breastfeeding.
Keep in a cool, dry place away from light.
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