Leroid 25 | 1 Strip Price in Bangladesh

✔️ Side Effects (usually from overdosage → hyperthyroidism symptoms)

General: Fatigue, weight loss, heat intolerance, sweating, fever.

CNS: Headache, insomnia, anxiety, irritability, hyperactivity.

Musculoskeletal: Tremors, muscle weakness.

Cardiovascular: Palpitations, tachycardia, arrhythmias, hypertension.

Respiratory: Dyspnea.

GI: Diarrhea, vomiting, abdominal cramps.

Skin: Hair loss, flushing.

✔️ Dosage & Administration

Adults

Initial: 25–50 mcg/day; increase by 12.5–25 mcg every 6–8 weeks until euthyroid and TSH normalized.

Severe hypothyroidism: Start at 12.5–25 mcg/day; increase by 25 mcg every 2–4 weeks with clinical/lab monitoring.

Secondary/Tertiary hypothyroidism: Adjust until free T4 is in the upper half of normal range.

Elderly or cardiac disease: ~1.7 mcg/kg/day, starting lower and titrating slowly.

Pediatric

Newborns: 10–15 mcg/kg/day; lower initial dose in cardiac risk infants, increase in 4–6 weeks as needed.

If serum T4 < 5 mcg/dL: start at 50 mcg/day.

Infants/Children (chronic/severe hypothyroidism): Start 25 mcg/day; increase every 2–4 weeks until target reached.

Weight-based dosing:

0–3 months: 10–15 mcg/kg/day

3–6 months: 8–10 mcg/kg/day

6–12 months: 6–8 mcg/kg/day

1–5 years: 5–6 mcg/kg/day

6–12 years: 4–5 mcg/kg/day

12 years, growth/puberty incomplete: 2–3 mcg/kg/day

Growth/puberty complete: 1.7 mcg/kg/day

✔️ Drug Interactions

Tricyclic/tetracyclic antidepressants: ↑ therapeutic/toxic effects; risk of arrhythmia & CNS stimulation.

Sertraline: May ↑ Leroid requirements.

Antidiabetics/insulin: May require ↑ doses; monitor glucose control.

Digitalis glycosides: ↓ serum levels and therapeutic effect after achieving euthyroid state.

✔️ Contraindications

• Untreated thyrotoxicosis
• Acute myocardial infarction
• Uncorrected adrenal insufficiency

✔️ Pregnancy & Lactation

Category A: Safe if dose adjusted; requirements may increase during pregnancy.

Minimal excretion in breast milk; adequate replacement needed for normal lactation.

✔️ Precautions

Adrenal insufficiency must be corrected before starting therapy.

Start low and go slow in elderly/cardiac patients to avoid arrhythmia or angina.

Adjust dose with major body weight changes.

Monitor TSH (primary hypothyroidism) or free T4 (central hypothyroidism).

✔️ Storage:

Store below 30°C, in a dry place, protected from light. Keep out of children’s reach.