Megestol Oral Suspension 100ml Price in Bangladesh

✔️ Uses of Megestol Oral Suspension

1. Breast Cancer:
   • Helps manage symptoms like lumps, nipple/breast shape changes, and bloody discharge from nipples.
2. Endometrial Cancer:
   • Addresses pelvic pain, bleeding between periods, and pain during sexual intercourse.

✔️ How does Megestol Oral Suspension work?

It acts by interfering with the production of hormones that cause cancer's development. It helps to reduce cancer symptoms effectively. It can also be used to treat loss of appetite in patients with HIV/AIDS.

✔️ Most side effects are manageable but consult your doctor if they persist or worsen:

1. Increased appetite and weight gain
2. Shortness of breath
3. Hot flushes (redness on the face and neck)
4. High blood pressure
5. Increased blood sugar levels
6. Rounded face (Cushingoid appearance)
7. Constipation
8. Swelling of a vein due to a blood clot (thrombophlebitis)

✔️ Antineoplastic Effects in Endometrial Cancer

• Exact Mechanism Unknown: Its antineoplastic effects are not fully understood.
• Gonadotropin Suppression: It inhibits pituitary gonadotropin production, reducing estrogen secretion, which may contribute to its effects against endometrial carcinoma.

✔️ Antineoplastic Effects in Breast Cancer

Modification of Steroid Hormones:

• Alters the actions of steroid hormones.
• Exerts a direct cytotoxic effect on tumor cells.
• Receptor Mechanism:
  • In metastatic cancer, tumor cells may or may not have hormone receptors.
  • Megestrol Acetate influences the estrogen-receptor mechanism, disrupting the cyclic process of estrogen activity in target cells.
  • It prevents estrogen from inducing gene transcription and altering cell functions.
• Reduction of Hormone-Dependent Cancer Cells:
  • High pharmacologic doses of Megestrol Acetate decrease hormone-dependent breast cancer cells.
  • It blocks or abolishes the stimulatory effects of estrogen on these cells.

✔️ Pharmacokinetics

Absorption:

• Peak plasma concentrations are reached 2–3 hours after a single oral dose of 160 mg.

Plasma Half-Life:

• The plasma half-life is 33–38 hours, allowing for sustained activity.

Excretion:

• Urine: ~66% of the administered dose is excreted via urine.
• Feces: ~20% of the dose is excreted in feces.

✔️ Dosage & Administration of Megestol Oral Suspension

The recommended adult initial dosage of Megestrol Oral Suspension is 800 mg/day (20 ml/day).

1. For Special Populations:
   • Elderly: Use with caution.
   • Children: Not recommended.
   • Pregnant and Breastfeeding Women: Not recommended.

✔️ Interaction

• Megestol Oral Suspension may interact with a medicine used to treat heart rhythm disorders (dofetilide) and an anticoagulant (warfarin).
• Megestol Oral Suspension should be used with caution in patients with severe liver problems, a history of thrombophlebitis (blood clots), stroke, adrenal gland disorder, and diabetes.

✔️ Do Not Use If

• Allergic to Megestrol or any of the tablet's contents.

✔️ Inform Your Doctor If You Have

• Severe liver problems
• History of thrombophlebitis or stroke
• Adrenal gland disorders
• Diabetes

✔️ Safety Information for Megestol Oral Suspension

1. Increased Risk of Blood Clots

• Caution in Thrombophlebitis History: Patients with a history of blood clots or thrombophlebitis should use this medication with caution.
• Signs of Blood Clots: Watch for the following symptoms and inform your doctor immediately:
  • Impaired coordination
  • Difficulty speaking
  • Pain in the groin
  • Pain in the arm or leg (especially in the calf)
  • Shortness of breath
  • General weakness
  • Headache or dizziness

2. Pregnancy Precautions

• Not Recommended During Pregnancy: Megestol Oral Suspension is contraindicated in pregnancy due to potential harm to the fetus.
• Contraception: Use a reliable contraceptive method to prevent pregnancy while on this medication.
• Pregnancy Test: You may need to undergo a pregnancy test before starting this medication.

3. Lactose Intolerance

• Contains Lactose: Inform your doctor if you have a known intolerance to sugars, as this medication contains lactose.

✔️ Storage Conditions:

• Keep Megestol Oral Suspension out of reach of children
• Do not store Megestol Oral Suspension above 25°C