Gefinix 250mg Tablet 10pcs Price in Bangladesh

✔️ Uses

• Non-small cell lung cancer

✔️ Reported adverse effects in NSCLC trials include:

• Common: Nausea (18%), asthenia (17%), pyrexia (9%), alopecia (4.7%).
• Less Common: Hemorrhage (4.3%), dry mouth (2%), dehydration (1.8%), allergic reactions (1.1%), elevated blood creatinine (1.5%), pancreatitis (0.1%).

✔️ How does

Gefinix 250 works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells.

✔️ Dosage & Administration

• Recommended Dose: 250 mg orally once daily, with or without food.
• Treatment is continued until disease progression or unacceptable toxicity.
• If a dose is missed, do not take it within 12 hours of the next scheduled dose.

✔️ Drug Interactions

1. CYP3A4 inducers (e.g., rifampicin, phenytoin, carbamazepine) can reduce Gefitinib levels.
2. CYP3A4 inhibitors (e.g., itraconazole, ketoconazole) can increase plasma concentrations.
3. Warfarin: May increase INR or bleeding risk.
4. Metoprolol: May have elevated blood levels when co-administered.
5. Vinorelbine: Gefitinib may exacerbate neutropenia caused by Vinorelbine.
6. Gastric pH-altering agents (e.g., PPIs, H2 antagonists) can reduce Gefitinib efficacy.

✔️ Contraindications

• Hypersensitivity to Gefitinib or its components.
• Lactation: Not recommended due to unknown excretion in breast milk.

✔️ Pregnancy & Lactation

• Pregnancy Category D:
  • Evidence shows potential fetal harm.
  • Use only if benefits outweigh risks (e.g., in life-threatening situations or where alternative treatments are ineffective).
• Lactation: Not recommended due to unknown excretion in breast milk.

✔️ Use with caution in

• Patients with idiopathic pulmonary fibrosis or new/worsening pulmonary or eye symptoms.
• Renal and hepatic dysfunction.
• Pregnant women.
• Monitoring Parameters:
  • Liver function tests.
  • Prothrombin time (PT) and INR.

✔️ Storage

• Store at 20-25°C in a cool, dry place.
• Keep out of the reach of children.