Brezofil Syrup 100ml Price in Bangladesh

✔️ Dosage & Administration of Brezofil Syrup

For Elderly Patients:

💊 200 mg tablet – twice or three times daily.

For Adults:

💊 400 mg tablet – twice or three times daily (or as prescribed by the physician).

For Children:

👦 Above 12 years: 10 ml syrup or 200 mg tablet – twice or three times daily.
👧 6-12 years: 6-9 mg/kg body weight, twice daily. (Example: If a child weighs 10 kg, the dose is 3 ml (60 mg) twice daily.)

🔹 If the daily requirement of Doxophylline is 400 mg, a sustained-release (SR) tablet should be taken once daily.

✔️ Possible Side Effects of Brezofil

Patients taking Brezofil may experience:
⚠ Common side effects:

• Nausea, vomiting, and stomach pain.
• Headache, irritability, and difficulty sleeping (insomnia).
• Rapid heartbeat (tachycardia) and irregular heartbeats (extrasystoles).
• Breathing difficulties (tachypnea).

⚠ Rare side effects:

• High blood sugar levels (hyperglycemia).
• Protein in urine (albuminuria).

⚠ Overdose Warning:

• May cause severe heart rhythm disturbances and tonic-clonic seizures.
• If overdose symptoms appear, discontinue use immediately and seek medical attention.
• Treatment may be resumed at lower doses once symptoms subside.

✔️ Drug Interactions – What to Avoid While Taking Brezofil?

🚫 Do not take Brezofil with other xanthine-based medications.
🚫 Limit the intake of caffeine-containing foods and beverages.
🚫 Caution is advised when used with:

• Ephedrine or other sympathomimetic drugs (may increase side effects).
• Antibiotics (Erythromycin, Lincomycin, Clindamycin, TAO) (may increase drug levels).
• Allopurinol, Cimetidine, Influenza vaccine, and Propranolol (may slow drug clearance, raising plasma levels).
• Phenytoin and anticonvulsants, as well as cigarette smoking, (may speed up drug clearance, reducing effectiveness).

✔️ Contraindications – Who Should Not Take Brezofil?

🚫 Do not use Brezofil if you have:
❌ Allergic reactions to Doxophylline or other xanthine derivatives.
❌ Recent heart attack (acute myocardial infarction).
❌ Low blood pressure (hypotension).
❌ Pregnancy and breastfeeding (contraindicated during lactation)

✔️ Overdose Management

🚨 Symptoms of overdose:

• Severe heart arrhythmias.
• Tonic-clonic seizures (convulsions).
• Signs of toxicity like extreme nausea, tremors, or agitation.

⚕ Treatment:

• There is no specific antidote.
• Symptomatic treatment should be provided to manage cardiovascular collapse.
• Discontinue the drug and seek immediate medical attention.

✔️ Use During Pregnancy & Lactation

Pregnant Women:

• Animal studies indicate that Doxophylline does not interfere with fetal development.
• However, due to limited clinical evidence, it should only be used if the benefits outweigh the risks.

Breastfeeding Mothers:

• Brezofil is contraindicated during lactation due to insufficient data on its presence in breast milk.

✔️ Precautions & Warnings

✅ Dosage Adjustments May Be Needed In:

• Elderly patients.
• Patients with chronic liver disease or severe infections.
• People with chronic obstructive pulmonary disease (COPD).
• Patients with heart conditions (hypertension, heart failure, or chronic corpulmonale).
• People with hyperthyroidism or severe low oxygen levels (hypoxemia).

📌 In patients with congestive heart failure, drug clearance is slower, leading to prolonged high blood levels even after discontinuation.

✅ No Risk of Addiction:

✔️ Storage Instructions

📌 Store in a dry place, away from light and heat.
📌 Keep out of reach of children.
📌 Use only as prescribed by a specialist physician.