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Indications

Fexofenadine Hydrochloride is used to treat the symptoms of seasonal allergic rhinitis in both adults and children. It's also used to treat the cutaneous signs of chronic idiopathic urticaria that aren't too severe.

Pharmacology

Fexofenadine Hydrochloride is an antihistamine that works by blocking peripheral H1 receptors. After oral administration, it is rapidly absorbed and reaches maximal plasma concentration in 2-3 hours. It doesn't appear to be able to pass through the blood-brain barrier.

Dosage & Administration

Seasonal Allergic Rhinitis-

Adults and children 12 years and older:

• Tablet: 60 mg twice daily or 120 mg once daily or 180 mg once daily
• In case of impaired renal function: 60 mg once daily

Children from 6 to 11 years:

• Tablet: 30 mg twice daily or 60 mg once daily
• In case of impaired renal function: 30 mg once daily
• Children from 2 to 11 years

Suspension: 30 mg or 5 ml twice daily

In case of impaired renal function: 30 mg or 5 ml once daily

Chronic Idiopathic Urticaria-

Adults and children 12 years and older:

• Tablet: 60 mg twice daily or 120 mg once daily or 180 mg once daily
• In case of impaired renal function: 60 mg once daily

Children from 6 to 11 years:

• Tablet: 30 mg twice daily or 60 mg once daily
• In case of impaired renal function: 30 mg once daily

Children from 6 months to less than 2 years:

• Suspension: 15 mg or 2.5 ml (1/2 tsp) twice daily
• In case of impaired renal function: 15 mg or 2.5 ml (1/2 tsp) once daily

Children from 2 to 11 years:

• Suspension: 30 mg or 5 ml (1 tsp) twice daily
• In case of impaired renal function: 30 mg or 5 ml (1 tsp) once daily.

Interaction

When taken with erythromycin or ketoconazole, the plasma levels of Fexofenadine Hydrochloride increased. Fexofenadine Hydrochloride absorption is reduced by antacids that contain aluminum and magnesium hydroxide.

Contraindications

Patients who have a known hypersensitivity to Fexofenadine Hydrochloride or any of its constituents should not take it.

Side Effects

Headache, lethargy, drowsiness, nausea, dry mouth, and gastrointestinal disorders are all common adverse effects.

Pregnancy & Lactation

Fexofenadine Hydrochloride is classified as pregnancy category C by the US Food and Drug Administration. So, unless the potential benefits to the other outweigh the potential hazards to the fetus, Fexofenadine Hydrochloride should be avoided during pregnancy and lactation.

Precautions & Warnings

Patients who are elderly or have impaired renal function should be treated with caution.

Storage Conditions

Keep away from light and heat in a dry location. Keep out of children's reach.